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Related Concept Videos

Development of Blood Vessels01:07

Development of Blood Vessels

663
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
663

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The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia
08:47

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Does Perinatal Intermittent Hypoxia Affect Cerebrovascular Network Development?

Vanessa Coelho-Santos1,2,3,4, Anne-Jolene N Cruz1, Andy Y Shih1,2,5

  • 1Center for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle, Washington, USA.

Developmental Neuroscience
|May 26, 2023
PubMed
Summary
This summary is machine-generated.

Chronic intermittent hypoxia (CIH) during development may impair brain blood vessel growth. This can lead to lasting issues in cerebrovascular function and contribute to neurodevelopmental disorders.

Keywords:
Cerebrovascular developmentChronic intermittent hypoxiaNeurodevelopmentOxygenPerinatal hypoxia

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Physiology

Background:

  • Perinatal hypoxia, particularly chronic intermittent hypoxia (CIH), affects premature infants.
  • CIH involves repetitive oxygen deprivation and reoxygenation, triggering brain inflammation and oxidative stress.
  • Cerebrovascular development is critical during gestation and early infancy, coinciding with CIH risk.

Purpose of the Study:

  • To explore the hypothesis that CIH disrupts normal cerebrovascular development.
  • To investigate the potential for CIH to create a feedback loop perpetuating metabolic insufficiency.
  • To understand long-term consequences of CIH on brain microvascular structure and function.

Main Methods:

  • This mini-review synthesizes existing knowledge on CIH and cerebrovascular development.
  • It discusses the proposed mechanisms linking CIH to impaired vascular growth.
  • The review examines the potential for lasting neurovascular deficits.

Main Results:

  • CIH is hypothesized to derail normal development of the brain's microvascular network.
  • This derailment may lead to a positive feedback loop exacerbating metabolic problems.
  • Abnormalities in vascular structure and function are suggested as consequences of CIH.

Conclusions:

  • CIH may induce permanent deficiencies in cerebrovascular function by disrupting development.
  • These vascular changes could contribute to the pathophysiology of neurodevelopmental disorders.
  • Further research is needed to confirm the impact of CIH on developing cerebrovasculature.