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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

334
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
414

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Related Experiment Video

Updated: Jul 29, 2025

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Optimizing the Cas13 antiviral train: cargo and delivery.

Shruti Sharma1, Cameron Myhrvold2

  • 1Department of Electrical and Computer Engineering, Princeton University, Princeton, NJ, USA.

EMBO Molecular Medicine
|May 26, 2023
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Summary

CRISPR-Cas13 technology offers a rapid response to emerging viral threats like SARS-CoV-2 by directly targeting viral RNA. This programmable approach allows for quick adaptation against evolving viruses, unlike traditional drug development.

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Area of Science:

  • Biotechnology
  • Molecular Biology
  • Infectious Disease Research

Background:

  • The 2020 SARS-CoV-2 pandemic underscored the urgent need for swift and scalable infectious disease countermeasures.
  • Traditional antiviral development timelines are lengthy, often exceeding 12-18 months, hindering rapid responses to novel pathogens.

Purpose of the Study:

  • To highlight the potential of CRISPR-Cas13 technology as a rapid-response antiviral therapeutic strategy.
  • To emphasize the programmability and adaptability of Cas13-based antivirals against emerging and evolving viruses.

Main Methods:

  • Utilizes CRISPR-Cas13 technology to directly target and cleave viral RNA.
  • Leverages the programmability of Cas13 systems for rapid therapeutic design.

Main Results:

  • CRISPR-Cas13 directly inhibits viral replication by cleaving viral RNA.
  • The programmable nature of Cas13 allows for swift adaptation to target new or mutated viruses.

Conclusions:

  • CRISPR-Cas13 represents a promising, rapidly deployable platform for combating emerging viral infections.
  • The adaptability of Cas13 antivirals mirrors that of mRNA vaccines, enabling effective responses to viral evolution.