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Correction: Kuc et al. Tension-Dominant Orthodontic Loading and Buccal Periodontal Phenotype Preservation: An Integrative Mechanobiological Model Supported by FEM and a Proof-of-Concept CBCT. <i>J. Funct. Biomater.</i> 2026, <i>17</i>, 47.

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Postproduction Processing of Electrospun Fibres for Tissue Engineering
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Direct-Writing Electrospun Functionalized Scaffolds for Periodontal Regeneration: In Vitro Studies.

Laura Bourdon1, Nina Attik1,2, Liza Belkessam1,2

  • 1Laboratoire des Multimatériaux et Interfaces, UMR 5615, CNRS, Université Claude Bernard Lyon 1, Bâtiment Chevreul, 6 Rue Victor Grignard, 69622 Villeurbanne, France.

Journal of Functional Biomaterials
|May 26, 2023
PubMed
Summary
This summary is machine-generated.

Direct-writing electrospinning created functional scaffolds for periodontal regeneration. These scaffolds, containing hydroxyapatite nanoparticles or cementum protein 1, successfully supported cell growth and mineralization, showing promise for complex tissue repair.

Keywords:
CEMP1bifunctionalcell mineralizationdirect-writingelectrospinninghydroxyapatite nanoparticlesperiodontal ligament cellsperiodontal regenerationscaffold

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Multiphasic scaffolds are ideal for complex tissue regeneration, like the periodontium.
  • Existing scaffolds often lack architectural precision and involve complex manufacturing, hindering clinical use.
  • Direct-writing electrospinning (DWE) offers a rapid method for creating 3D scaffolds with controlled architecture.

Purpose of the Study:

  • To develop a biphasic scaffold using DWE for periodontal regeneration.
  • To incorporate hydroxyapatite nanoparticles (HAP) and cementum protein 1 (CEMP1) for bone and cementum regeneration.
  • To evaluate the scaffold's effect on periodontal ligament (PDL) cell behavior.

Main Methods:

  • Fabrication of a biphasic scaffold using DWE with two polycaprolactone solutions.
  • Functionalization of scaffold parts with HAP nanoparticles and CEMP1.
  • Morphological characterization of scaffolds.
  • Assessment of PDL cell proliferation, colonization, and mineralization on scaffolds.

Main Results:

  • Scaffolds were successfully fabricated with controlled architecture using DWE.
  • Both HAP- and CEMP1-functionalized scaffolds supported PDL cell colonization.
  • Functionalized scaffolds demonstrated enhanced mineralization compared to unfunctionalized controls, confirmed by alizarin red staining and OPN expression.

Conclusions:

  • Functionalized, organized scaffolds show potential for stimulating bone and cementum regeneration.
  • DWE is a viable technique for creating smart scaffolds with controlled cellular orientation for tissue regeneration.
  • This approach could significantly advance periodontal and other complex tissue regeneration strategies.