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Related Experiment Videos

Interactions between verapamil and morphine on physiological parameters in rats.

M Szikszay, F R Snyder, E D London

    The Journal of Pharmacology and Experimental Therapeutics
    |July 1, 1986
    PubMed
    Summary

    Verapamil, a calcium channel blocker, lessened morphine

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    Area of Science:

    • Pharmacology
    • Cardiovascular Physiology
    • Respiratory Physiology

    Background:

    • Morphine is a potent opioid analgesic with known respiratory depressant effects.
    • Verapamil is a calcium channel antagonist with cardiovascular effects.
    • Interactions between opioids and calcium channel blockers require further investigation.

    Purpose of the Study:

    • To investigate the combined effects of morphine and verapamil on respiratory and cardiovascular parameters in rats.
    • To determine if verapamil modulates morphine-induced respiratory depression.
    • To assess the impact of verapamil on morphine's cardiovascular effects.

    Main Methods:

    • Fischer-344 rats were administered subcutaneous doses of morphine and verapamil, alone and in combination.
    • Arterial blood gases, pH, mean blood pressure, and heart rate were monitored.
    • Dose-dependent effects of morphine and verapamil were assessed.

    Main Results:

    • Morphine caused dose-dependent respiratory depression (hypoxia, hypercapnia, acidosis).
    • Verapamil attenuated and delayed morphine's respiratory effects.
    • Verapamil significantly reduced blood pressure, an effect seen even with combined administration.
    • Verapamil antagonized morphine-induced tachycardia.

    Conclusions:

    • Verapamil mitigates morphine's respiratory depressant effects in rats.
    • The interaction of verapamil with morphine's respiratory actions differs from its effects on antinociception and hypothermia.
    • These findings suggest complex pharmacological interactions between verapamil and morphine.

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