Relationship Between High Sensitivity C-reactive Protein to Albumin Ratio With Infarct-related Artery Patency in...

Area of Science:

• Cardiology
• Biomarkers
• Acute Coronary Syndromes

Background:

• The C-reactive protein/albumin ratio (CAR) is an emerging prognostic marker.
• Its association with infarct-related artery (IRA) patency in non-ST-segment elevation myocardial infarction (NSTEMI) requires investigation.

Purpose of the Study:

• To investigate the relationship between serum CAR and IRA patency in NSTEMI patients.
• To determine if CAR can predict pre-procedural IRA occlusion.

Main Methods:

• A cohort of 700 NSTEMI patients undergoing percutaneous coronary intervention was analyzed.
• Patients were grouped based on pre-procedural IRA patency (TIMI flow grades 0-1 for occluded, 2-3 for patent).
• Statistical analysis, including logistic regression and ROC curve assessment, was performed.

Main Results:

• High CAR was an independent predictor of occluded IRA (Odds Ratio: 3.153, P < .001).
• CAR correlated positively with SYNTAX score, neutrophil/lymphocyte ratio, and platelet/lymphocyte ratio.
• CAR showed negative correlation with left ventricular ejection fraction.
• A CAR cut-off of 0.18 predicted occluded IRA with 68.3% sensitivity and 67.9% specificity (AUC = 0.744).

Conclusions:

• Serum CAR is a significant predictor of pre-procedural IRA occlusion in NSTEMI patients.
• CAR may serve as a valuable biomarker for assessing IRA status in NSTEMI.
• Further research can explore CAR's role in guiding NSTEMI management.