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Encapsulation of Bioactive Peptides by Spray-Drying and Electrospraying
Carmen Berraquero-García1, Raúl Pérez-Gálvez1, F Javier Espejo-Carpio1
1Department of Chemical Engineering, University of Granada, 18071 Granada, Spain.
Foods (Basel, Switzerland)
|May 27, 2023
Summary
Encapsulating bioactive peptides using spray-drying and electrospraying techniques enhances their stability and oral delivery. Coaxial configurations show promise for improved protection of these valuable compounds.
Area of Science:
- Food Science and Technology
- Biotechnology
- Pharmaceutical Sciences
Background:
- Bioactive peptides from enzymatic hydrolysis are valuable for supplements, pharmaceuticals, and functional foods.
- Oral delivery of bioactive peptides is limited by gastrointestinal degradation, reducing their efficacy.
- Encapsulation techniques stabilize functional ingredients, improving bioaccessibility through protection during processing, storage, and digestion.
Purpose of the Study:
- To review the application of monoaxial and coaxial spray-drying and electrospraying for encapsulating bioactive peptides.
- To analyze factors influencing encapsulate properties, including formulation, carrier/solvent selection, and processing conditions.
- To assess the release, bioactivity retention, and stability of encapsulated peptides post-processing and digestion.
Main Methods:
- Review of existing literature on monoaxial and coaxial spray-drying and electrospraying for peptide encapsulation.
- Analysis of formulation parameters (feed solution, carrier, solvent) and processing conditions.
- Evaluation of encapsulation efficiency, particle characteristics, bioactivity retention, and in vitro/in vivo stability.
Main Results:
- Monoaxial and coaxial spray-drying and electrospraying are effective for encapsulating bioactive peptides.
- Coaxial configurations potentially offer superior stabilization of protein-based bioactives through shell-core structures.
- Formulation and processing parameters significantly impact the properties and performance of the encapsulates.
Conclusions:
- Encapsulation via spray-drying and electrospraying, particularly with coaxial configurations, can enhance the stability and bioaccessibility of bioactive peptides for oral delivery.
- Optimization of formulation and processing conditions is crucial for maximizing the benefits of encapsulated bioactive peptides.
- Further research into coaxial techniques is warranted for improved stabilization of protein-based bioactives.
