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Related Concept Videos

Imprinting01:22

Imprinting

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Behavioral imprinting is observed in some newborn animals and occurs when they develop strong and specific attachments to another animal (usually a parent) following brief, early-life exposures. Offspring imprint onto parents within a brief period after birth or hatching; this time window is called the critical period. Once imprinting occurs, the bond established between the parents and their offspring is usually long-lasting.
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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
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Transcriptome Profiling of In-Vivo Produced Bovine Pre-implantation Embryos Using Two-color Microarray Platform
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Defining Candidate Imprinted loci in Bos taurus.

Minou Bina1

  • 1Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.

Genes
|May 27, 2023
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Summary
This summary is machine-generated.

This study identifies cattle imprinting control regions (ICRs) using a bioinformatics strategy. These regions are crucial for embryogenesis and influence key developmental processes like spermatogenesis and muscle growth.

Keywords:
BCL6CNNM1CNR1SIX1ZFBS-morph overlapsZFP57bull spermatogenesiscattle genomicscattle musclecattle spermatogenesisfarm animalsgenome widegenomic imprinting

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Area of Science:

  • Genomics
  • Bioinformatics
  • Developmental Biology

Background:

  • Genomic imprinting is vital for mammalian embryogenesis.
  • Imprinting control regions (ICRs) regulate imprinted gene expression.
  • Understanding cattle ICRs is important for agricultural and biological research.

Purpose of the Study:

  • To develop and apply a bioinformatics strategy for genome-wide identification of cattle imprinting control regions (ICRs).
  • To identify candidate imprinted genes associated with spermatogenesis and muscle development in cattle.
  • To leverage mouse ENCODE data to infer regulatory mechanisms for cattle.

Main Methods:

  • Whole-genome assembly of *Bos taurus* was used.
  • A bioinformatics strategy was employed to locate candidate ICRs, visualized as peaks.
  • Analysis of mouse ENCODE data, specifically DNase I hypersensitive sites (DHSs), was performed.

Main Results:

  • Candidate ICRs were identified across the *Bos taurus* genome.
  • Genes near candidate ICRs, such as *CNNM1*, *CNR1*, *SIX1*, and *BCL6*, were linked to spermatogenesis and muscle development.
  • Mouse ENCODE data indicated chromatin accessibility at *SIX1* and *BCL6* loci in relevant cell types.

Conclusions:

  • The bioinformatics strategy effectively identifies potential ICRs in cattle.
  • Candidate ICRs and associated genes provide insights into cattle development and gene regulation.
  • Cross-species data analysis (mouse to cattle) can inform regulatory mechanism studies.