Multiple Bioimaging Applications Based on the Excellent Properties of Nanodiamond: A Review

Area of Science:

• Biomaterials Science
• Nanotechnology
• Optical Imaging

Background:

• Traditional fluorescent dyes present limitations in physical, optical, and toxicity aspects for bioscience research.
• Nanodiamonds (NDs) possess unique optical and spectroscopic properties, making them promising for multimodal bioimaging.
• Optically active color centers within NDs enable fluorescence and offer enhanced sensitivity and photostability.

Purpose of the Study:

• To review the recent advancements in nanodiamond applications for multimodal bioimaging.
• To summarize progress across various imaging modalities utilizing nanodiamonds.
• To provide an outlook on future nanodiamond exploration in bioimaging.

Main Methods:

• Review of recent literature on nanodiamonds in bioimaging.
• Summarization of applications in fluorescence imaging, Raman imaging, X-ray imaging, magnetic modulation fluorescence imaging, magnetic resonance imaging, cathodoluminescence imaging, and optical coherence tomography.
• Analysis of nanodiamond properties relevant to bioimaging probes.

Main Results:

• Nanodiamonds demonstrate significant advantages over traditional fluorescent dyes for bioimaging.
• NDs are effectively utilized as fluorescent labeling tools and biomarkers.
• Diverse imaging modalities, including fluorescence, Raman, MRI, and X-ray, benefit from nanodiamond integration.

Conclusions:

• Nanodiamonds are a versatile and advantageous tool for multimodal bioimaging.
• Their unique properties facilitate advancements in bioscience research and biomarker development.
• Continued exploration of nanodiamonds promises further innovation in bioimaging technologies.