Related Experiment Video

Updated: Jul 29, 2025

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

16.2K

Antimicrobial Resistance in Organ Transplant Recipients

Maddalena Giannella1, Matteo Rinaldi1, Pierluigi Viale1

  • 1Infectious Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Via Massarenti 11, Bologna 40137, Italy.

Infectious Disease Clinics of North America
|May 27, 2023
PubMed

Insights

Multidrug-resistant organisms (MDROs) pose a significant threat to solid organ transplant (SOT) recipients, impacting graft and patient outcomes. Management strategies, including prevention and novel non-antibiotic approaches, are crucial for this vulnerable population.

Area of Science:

  • Infectious Diseases
  • Transplantation Medicine
  • Microbiology

Background:

  • Solid organ transplant (SOT) recipients are highly susceptible to infections.
  • Bacterial multidrug-resistant organisms (MDROs) represent a growing clinical challenge in SOT populations.
  • Key MDROs include MRSA, VRE, ESBL-producing Enterobacterales, CRE, MDR P. aeruginosa, and CR A. baumannii.

Purpose of the Study:

  • To summarize the burden of MDROs in SOT recipients, including prevalence, incidence, and risk factors.
  • To review the impact of MDROs on graft and patient outcomes across different SOT types.
  • To explore the role of MDROs in donor-derived infections and discuss management strategies.

Main Methods:

  • Comprehensive literature review and data synthesis.
  • Analysis of prevalence, incidence, risk factors, and outcomes related to MDROs in SOT.
  • Review of donor-derived infections and current/emerging management strategies.

Main Results:

  • MDROs significantly increase morbidity and mortality in SOT recipients.
  • Specific MDROs have varying impacts depending on the type of SOT.
  • Donor-derived infections are a critical transmission route for MDROs.

Conclusions:

  • Effective prevention and treatment of MDROs are essential for improving SOT outcomes.
  • Current management involves antibiotic strategies, but challenges remain.
  • Non-antibiotic-based strategies offer promising future directions for MDRO control in SOT.
Keywords:
Antibiotic prophylaxisDifficult to treat bacteriaEarly treatmentGraft failureMortalityMultidrug-resistant bacteriaPreventionSurveillance

More Related Videos

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

4.4K
Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection05:10

Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection

Published on: August 20, 2007

6.1K

Related Concept Videos

Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
37
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
29
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
420
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
41
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
69.2K
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
50