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A Method to Study Adaptation to Left-Right Reversed Audition
Published on: October 29, 2018
Alterations in Resting-State Interhemispheric Coordination With Refractory Auditory Verbal Hallucinations in
Huichang Qian1, Xiaozheng Liu1, Zhongwei Guo1
1School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China (Qian, J. Liu); Department of Radiology, Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China (X. Liu); Department of Psychiatry, Tongde Hospital of Zhejiang Province, Hangzhou, China (Guo); and Departments of Radiology (Wang), Psychogeriatrics (Chen), and Science and Education (J. Liu), Hangzhou Seventh People's Hospital, Hangzhou, China.
Objective:
The purpose of this study was to investigate resting-state interhemispheric functional connectivity in patients with schizophrenia and refractory auditory verbal hallucinations (RAVHs) by using voxel-mirrored homotopic connectivity (VMHC).
Methods:
Thirty-four patients with schizophrenia and RAVHs (RAVH group), 23 patients with schizophrenia but no auditory verbal hallucinations (non-AVH group), and 28 matched healthy volunteers (healthy control group) were recruited in China. VMHC analyses were used to identify brain areas with significant differences in functional connectivity among the three groups, and correlations between symptom scores and neurological measures were examined.
Results:
VMHC analyses showed aberrant bilateral connectivity between several homotopic brain regions: the RAVH and non-AVH groups showed differences in bilateral connectivity of the superior and middle temporal gyri, and the RAVH and healthy control groups showed differences in bilateral connectivity of the gyrus rectus, inferior frontal gyrus, and putamen. In addition, interhemispheric connectivity of the superior and middle temporal gyri correlated with patients' positive symptom scores.
Conclusions:
These findings may help to elucidate the pathophysiological mechanisms underlying auditory verbal hallucinations. The results revealed interhemispheric functional dysconnectivity among patients with schizophrenia and suggest that the dysconnectivity of homotopic brain regions may play an important role in the development of auditory verbal hallucinations.
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