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Updated: Jul 28, 2025
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Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
Published on: April 11, 2018
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Recurrent peripartum alveolar soft-part sarcoma: Case report using CARE methodology
F Carsuzaa1, M Fieux2, X Piguel3
1Service ORL, chirurgie cervico-maxillo-faciale et audiophonologie, CHU de Poitiers, 86000 Poitiers, France.
Summary
Alveolar soft-part sarcoma (ASPS) can recur during pregnancy, showing progesterone sensitivity. This suggests progesterone blockers may offer a new treatment for recurrent ASPS.
Area of Science:
- Oncology
- Pathology
Background:
- Alveolar soft-part sarcoma (ASPS) is a rare malignancy, infrequently occurring in the head and neck region.
- Hormone-dependent recurrence of ASPS has not been previously documented.
Observation:
- A 35-year-old woman experienced multiple ASPS occurrences, including during two pregnancies.
- Tumor progression and metastasis led to a fatal outcome.
Findings:
- Pathology revealed progesterone receptor positivity in tumors from peripartum episodes.
- This case represents the first report of peripartum ASPS recurrence with significant progesterone sensitivity.
Implications:
- The findings suggest a potential biological link between ASPS and progesterone.
- Progesterone blockers may represent a novel therapeutic strategy for recurrent ASPS.
