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The aggregate index of systemic inflammation (AISI): a novel predictor for hypertension

Jiaming Xiu1,2, Xueqin Lin1,2, Qiansheng Chen1

  • 1Department of Cardiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

Frontiers in Cardiovascular Medicine
|June 2, 2023
PubMed

Insights

Elevated systemic inflammation, measured by the Aggregate Index of Systemic Inflammation (AISI), is linked to higher cardiovascular mortality risk in hypertension patients. This marker may signal a poor prognosis.

Area of Science:

  • Cardiovascular Medicine
  • Inflammation Research
  • Public Health

Background:

  • Hypertension (HTN) pathophysiology involves inflammation.
  • The Aggregate Index of Systemic Inflammation (AISI) is a novel inflammatory and prognostic marker.

Purpose of the Study:

  • To investigate the association between hypertension and AISI.
  • To determine if AISI predicts cardiovascular mortality in hypertensive adults.

Main Methods:

  • Analysis of National Health and Nutrition Examination Survey (NHANES) data (1999-2018).
  • Inclusion of 23,765 participants with hypertension.
  • Assessment of cardiovascular mortality risk using survival curves and Cox regression, stratified by AISI quartiles.

Main Results:

  • High AISI levels significantly correlate with increased cardiovascular mortality in hypertensive patients.
  • The highest AISI quartile (Q4) showed a significantly higher risk of cardiovascular mortality (HR: 1.91) compared to the lowest (Q1).
  • Associations remained consistent across subgroups for age, gender, and obesity.

Conclusions:

  • Elevated AISI is significantly associated with increased cardiovascular mortality in adults with hypertension.
  • AISI may function as an early warning indicator for adverse cardiovascular outcomes in hypertensive individuals.
Abstract

Keywords:
NHANESaggregate index of systemic inflammationcardiovascular mortalityhypertensioninflammation

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