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Related Concept Videos

Neural Regulation01:37

Neural Regulation

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Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Related Experiment Video

Updated: Jul 28, 2025

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis
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Evolving markers in amyotrophic lateral sclerosis.

Xu Chen1, Lu Zhou2, Can Cui3

  • 1Baoan Women's and Children's Hospital-Shenzhen University, Shenzhen, P.R. China.

Advances in Clinical Chemistry
|June 2, 2023
PubMed
Summary
This summary is machine-generated.

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. Current research reviews potential diagnostic and prognostic markers for ALS, though none are clinically validated yet.

Keywords:
Amyotrophic lateral sclerosisMarkerMotor neuronMulti-omicsPathophysiology

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Area of Science:

  • Neuroscience
  • Biomarkers
  • Neurodegenerative Diseases

Background:

  • Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron loss.
  • Despite advancements in diagnostic technologies, no definitive clinical biomarkers for ALS have been established.

Purpose of the Study:

  • To review current research on markers associated with ALS pathophysiology.
  • To explore the potential of these markers in ALS diagnosis, prognosis, and therapeutic strategies.

Main Methods:

  • Literature review of studies utilizing electromyography, imaging, and multi-omics.
  • Analysis of identified functional, structural, circulating, and microbiota markers.

Main Results:

  • Numerous potential markers for ALS have been suggested by various technologies.
  • No biomarkers have achieved clinical validation for ALS diagnosis or management to date.

Conclusions:

  • Continued research is crucial for identifying and validating reliable biomarkers for ALS.
  • Validated markers could significantly improve early diagnosis, prognosis prediction, and treatment efficacy in ALS.