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Shiya Zhao1, Yuanjiao Yang1, Yuru Wang1

  • 1State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China. hxju@nju.edu.cn.

Chemical Communications (Cambridge, England)
|June 5, 2023
PubMed
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Researchers developed a novel dendrimer probe for in vivo identification of sialic acid groups. This dual-color imaging strategy enables semiquantitative evaluation of sialylation in tumor tissues, aiding clinical diagnosis.

Area of Science:

  • Biomedical Engineering
  • Molecular Imaging
  • Cancer Diagnostics

Background:

  • Sialic acids play crucial roles in biological processes, including cancer progression.
  • Identifying and quantifying sialic acid expression in vivo is vital for understanding disease mechanisms and diagnosis.

Purpose of the Study:

  • To design a functional dendrimer probe for convenient in vivo identification of newly generated sialic acid groups.
  • To develop a dual-color imaging strategy for in situ semiquantitative evaluation of sialylation.
  • To reveal sialylation-related biological events and promote clinical tumor diagnosis.

Main Methods:

  • Design and synthesis of a functional dendrimer probe.
  • In vivo dual-color imaging strategy.
  • Semiquantitative analysis of sialylation in tumor versus normal tissues.

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Main Results:

  • The dendrimer probe successfully identified newly generated sialic acid groups in vivo.
  • The dual-color imaging strategy enabled accurate in situ semiquantitative evaluation of sialylation.
  • Significant differences in sialylation were observed between tumor and normal tissues.

Conclusions:

  • The developed dendrimer probe and imaging strategy offer a convenient tool for in vivo sialylation assessment.
  • This approach can reveal critical sialylation-related biological events in cancer.
  • The findings support the potential of this method for promoting clinical tumor diagnosis.