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Anzhao Wang1,2,3, Zhicheng Wei1,2,3, Haolin Yuan1,2,3

  • 1Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Frontiers in Neuroscience
|June 5, 2023
PubMed
Summary

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Genetic variants in the FKBP5 gene are linked to obstructive sleep apnea (OSA) severity and sleep disturbances, particularly in men. These FKBP5 single nucleotide polymorphisms (SNPs) may predispose individuals to sleep disorders, especially during REM sleep.

Area of Science:

  • Genetics
  • Sleep Medicine
  • Psychiatry

Background:

  • Obstructive sleep apnea (OSA) is frequently comorbid with psychiatric conditions like depression and PTSD.
  • FKBP5 gene variants are known risk factors for depression and PTSD.
  • The potential genetic links between FKBP5 and OSA require further investigation.

Purpose of the Study:

  • To investigate the association between FKBP5 single nucleotide polymorphisms (SNPs) and obstructive sleep apnea (OSA).
  • To examine the relationship between FKBP5 SNPs and OSA-related quantitative traits.
  • To explore the potential role of FKBP5 variants in sleep disorders.

Main Methods:

  • Genotyped four FKBP5 SNPs (rs1360780, rs3800373, rs9296158, rs9470080) in 5773 participants.
  • Utilized linear and logistic regression analyses for OSA susceptibility and trait evaluation.
Keywords:
FKBP5 genedepressionobstructive sleep apneaposttraumatic stress disordersingle nucleotide polymorphism

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  • Performed eQTL and gene expression analyses to understand SNP regulatory effects.

    • Main Results:

    • All four FKBP5 SNPs were associated with AHIREM in moderate-to-severe OSA patients.
    • Specific SNPs correlated with increased wake time in men with moderate OSA and higher MAI categories.
    • Certain SNPs increased the risk of low sleep efficiency, with potential regulation of FKBP5, TULP1, and ARMC12.

    Conclusions:

    • FKBP5 gene polymorphisms are associated with sleep respiratory events during REM sleep in OSA patients.
    • These variants are linked to sleep architecture alterations in men with moderate OSA.
    • FKBP5 variants may represent a predisposing genetic factor for sleep disorders, particularly REM sleep disturbances.