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Homocysteine levels, H-Hypertension, and the MTHFR C677T genotypes: A complex interaction
Cynthia Al Hageh1, Eman Alefishat1,2,3, Michella Ghassibe-Sabbagh4
1College of Medicine and Health Sciences, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates.
Heliyon
|June 5, 2023
Summary
High homocysteine levels increase hypertension and stroke risk. The methylenetetrahydrofolate reductase (MTHFR) T allele and TT genotype are linked to higher homocysteine, hypertension, and stroke risk, especially with diuretic use.
Area of Science:
- Genetics and Cardiovascular Health
- Biochemistry and Disease Risk
- Pharmacogenomics
Background:
- Elevated homocysteine levels are a known risk factor for hypertension and stroke.
- The methylenetetrahydrofolate reductase (MTHFR) enzyme plays a key role in homocysteine metabolism.
- The C677T polymorphism in the MTHFR gene may influence homocysteine levels and associated health risks.
Purpose of the Study:
- To investigate homocysteine levels in relation to MTHFR C677T genotypes.
- To examine the association between homocysteine, hypertension, stroke, and antihypertensive medication use.
- To identify potential genotype-specific risks and therapeutic implications.
Main Methods:
- Genotyping for MTHFR C677T polymorphism in 2,640 Lebanese adults.
- Measurement of plasma homocysteine levels.
- Documentation of hypertension, stroke history, and medication use.
Main Results:
- The MTHFR TT genotype and T allele were more prevalent in patients with hyperhomocysteinemia and hypertension.
- Hypertensive patients, particularly those on diuretics, exhibited significantly higher homocysteine levels.
- Homocysteine levels correlated with stroke risk in MTHFR T allele carriers.
Conclusions:
- An association exists between homocysteine, hypertension, medication use, and stroke risk in individuals with the MTHFR T allele and TT genotype.
- Diuretic therapy is linked to increased homocysteine levels, suggesting a need for monitoring and management.
- Routine homocysteine measurement and control in patients on diuretics may improve health outcomes.
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