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Glottic Neurofibroma: An Unusual Case Report
Nupur Kapoor Nerurkar1, Asitama Sarkar1
1Bombay Hospital Voice and Swallowing Centre, Bombay Hospital and Medical Research Centre, 2nd Floor MRC, Mumbai, Maharashtra 400020 India.
Summary
This case report details a rare glottic neurofibroma in an elderly male presenting with hoarseness. Surgical excision and S-100 protein immunohistochemistry confirmed the diagnosis, with regular follow-up recommended.
Area of Science:
- Otolaryngology
- Head and Neck Surgery
- Pathology
Background:
- Solitary neurofibromas of the larynx are rare, typically affecting the aryepiglottic folds.
- Non-plexiform glottic neurofibromas are exceptionally uncommon and distinct from plexiform variants often linked to Von Recklinghausen's disease.
Purpose of the Study:
- To report an unusual case of an isolated glottic neurofibroma.
- To highlight diagnostic challenges and successful surgical management of this rare laryngeal tumor.
Main Methods:
- A case study of an elderly male with progressive hoarseness.
- Diagnostic evaluation included stroboscopy and histopathological examination with immunohistochemistry (S-100 protein).
- Surgical intervention involved laser-assisted trans-oral microlaryngeal surgery with a micro-flap technique for complete lesion excision.
Main Results:
- Histopathology confirmed a neurofibromatous lesion.
- Immunohistochemistry was positive for S-100 protein, validating the diagnosis.
- The patient experienced resolution of symptoms post-surgery.
Conclusions:
- Isolated glottic neurofibroma is a rare entity that can present as a unilateral subepithelial lesion.
- Prompt diagnosis and complete surgical excision are crucial for management.
- Regular follow-up is advised to monitor for potential recurrence.
