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Related Concept Videos

Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Integrating Precision Medicine into Medical Dermatology Clinical Practice: An Expert Consensus Panel.

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    Precision medicine, using genomics, can improve psoriasis treatment by identifying biomarkers for optimal biologic selection. This expert consensus supports a targeted, evidence-based approach over trial-and-error for better patient outcomes.

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    Area of Science:

    • Dermatology
    • Genomics
    • Precision Medicine

    Background:

    • Precision medicine leverages individual genomics for enhanced diagnosis, prognosis, and therapy.
    • Dermatology guidelines highlight the need for biomarkers to predict optimal biologic agents for psoriasis patients.
    • This paper reviews precision medicine's current role in dermatology and its potential to improve psoriasis outcomes.

    Purpose of the Study:

    • To examine the current state of precision medicine in dermatology.
    • To assess how precision medicine can improve outcomes in psoriasis treatment.

    Main Methods:

    • A systematic literature search was conducted using PubMed/MEDLINE.
    • Relevant articles were identified using keywords: precision medicine, personalized medicine, biomarkers, genomics, and dermatology.
    • An expert consensus panel used a modified Delphi approach to assign evidence levels and create consensus statements.

    Main Results:

    • Thirteen articles met the inclusion criteria and were assigned evidence levels.
    • The expert panel developed 10 consensus statements on improving patient outcomes with precision medicine.
    • All consensus statements achieved unanimous agreement from the panel.

    Conclusions:

    • Current psoriasis biologic selection often involves trial-and-error.
    • Precision medicine tests can identify patient-specific biomarkers.
    • This enables targeted, evidence-based selection of optimal medications, improving psoriasis care.