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A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy
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A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy

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Changes of Functional Brain Network in Neonates with Different Degrees of Hypoxic-Ischemic Encephalopathy

Yingying Wang1, Yi Wang2, Guowei Hua1

  • 1Department of Neonatology, Affiliated Changzhou Children's Hospital of Nantong University, Changzhou, China.

Brain Connectivity
|June 6, 2023
PubMed

Insights

Moderate to severe hypoxic-ischemic encephalopathy (HIE) in newborns is linked to reduced brain functional connectivity compared to mild HIE. This impacts emotional processing, sensory-motor skills, and cognitive functions in affected infants.

Area of Science:

  • Neuroscience
  • Pediatric Neurology
  • Medical Imaging

Background:

  • Neonatal hypoxic-ischemic encephalopathy (HIE) is a leading global cause of neonatal mortality and long-term disability.
  • Limited research exists on using resting-state functional magnetic resonance imaging (rs-fMRI) to study brain development in HIE children.

Purpose of the Study:

  • To investigate alterations in brain function in neonates with varying degrees of HIE using rs-fMRI.
  • To compare functional brain network connectivity between mild and moderate-to-severe HIE groups.

Main Methods:

  • Recruited 44 HIE patients (21 mild, 23 moderate/severe) between February 2018 and May 2020.
  • Utilized conventional and functional MRI scans.
  • Applied amplitude of low-frequency fluctuation and brain network edge analysis.

Main Results:

  • Moderate-to-severe HIE group showed significantly reduced functional connectivity.
  • Key areas with decreased connectivity included connections between the right supplementary motor area and right precentral gyrus, right lingual gyrus and right hippocampus, left calcarine cortex and right amygdala, and right pallidus and right posterior cingulate cortex.
  • These reductions were statistically significant (p < 0.001, uncorrected).

Conclusions:

  • Infants with moderate-to-severe HIE exhibit distinct patterns of altered brain functional connectivity compared to those with mild HIE.
  • Findings suggest developmental lags in emotional processing, sensory-motor skills, cognitive function, and learning/memory in moderate-to-severe HIE neonates.
  • rs-fMRI is a valuable tool for assessing brain function in HIE.

Keywords:
functional brain networkfunctional connectivityhypoxic–ischemic encephalopathyresting-state functional magnetic resonance imaging

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