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Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

10
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

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IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
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Therapeutic Scleral Lens Management of Corneal Epithelial Hypertrophy Secondary to a Corneal Persistent Epithelial Defect: A Case Report.

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Updated: Jul 27, 2025

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Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures

Published on: November 22, 2024

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Necrotizing Scleritis: A Review.

Parthopratim Dutta Majumder1, Shweta Agarwal2, Mauli Shah1

  • 1Department of Uvea Services, Medical Research Foundation, Sankara Nethralaya, Chennai, India.

Ocular Immunology and Inflammation
|June 6, 2023
PubMed
Summary
This summary is machine-generated.

Necrotizing scleritis, a severe eye condition, often links to autoimmune diseases or infections. Differentiating between infectious and non-infectious causes is crucial for effective treatment and preventing vision loss.

Keywords:
BiologicsGranulomatosis with polyangiitisimmunosuppressivesinfectionnecrotizing scleritis

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Area of Science:

  • Ophthalmology
  • Rheumatology
  • Infectious Diseases

Background:

  • Necrotizing scleritis is the most destructive and vision-threatening form of scleritis.
  • It can be associated with systemic autoimmune disorders, systemic vasculitis, or microbial infections.
  • Rheumatoid arthritis and granulomatosis with polyangiitis are common systemic diseases linked to necrotizing scleritis.

Purpose of the Study:

  • To highlight the critical importance of differentiating between infectious and non-infectious necrotizing scleritis.
  • To discuss the management strategies for both forms of necrotizing scleritis.
  • To emphasize the complications associated with necrotizing scleritis.

Main Methods:

  • Review of literature on necrotizing scleritis.
  • Analysis of common causes, risk factors, and associated systemic diseases.
  • Comparison of treatment modalities for infectious and non-infectious necrotizing scleritis.

Main Results:

  • Pseudomonas species is the most common cause of infectious necrotizing scleritis, with surgery being a common risk factor.
  • Necrotizing scleritis has high complication rates, including secondary glaucoma and cataract.
  • Distinguishing between infectious and non-infectious forms is challenging but essential for management.

Conclusions:

  • Non-infectious necrotizing scleritis requires aggressive immunosuppressive therapy.
  • Infectious necrotizing scleritis necessitates long-term antimicrobial treatment and surgical intervention due to deep infection and scleral avascularity.