Related Experiment Video

Updated: Jul 27, 2025

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
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Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

Published on: May 10, 2021

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Calcium Load in the Aortic Valve, Aortic Root, and Left Ventricular Outflow Tract and the Risk for a Periprocedural

Henrik Bjursten1, Sasha Koul2, Olov Duvernoy3

  • 1Department of Cardiothoracic Surgery, Skåne University Hospital, Lund University, Lund, Sweden.

Structural Heart : the Journal of the Heart Team
|June 8, 2023
PubMed

Insights

This study found no specific calcification patterns predicting stroke risk after transcatheter aortic valve implantation. Further research is needed to understand periprocedural stroke in these patients.

Area of Science:

  • Cardiology
  • Neurology
  • Radiology

Background:

  • Periprocedural stroke is a rare but severe complication of transcatheter aortic valve implantation (TAVI).
  • Aortic valve calcification is the suspected source of emboli causing stroke during TAVI.
  • Variations in calcification patterns may influence stroke risk.

Purpose of the Study:

  • To investigate if specific patterns of calcification in the left ventricular outflow tract, annulus, aortic valve, and ascending aorta can predict periprocedural stroke risk in TAVI patients.

Main Methods:

  • Retrospective analysis of 52 patients with periprocedural stroke and 52 matched controls from a cohort of 3282 TAVI patients.
  • Blind review of cardiac computed tomography scans by an experienced radiologist to assess 39 calcium pattern metrics.

Main Results:

  • No significant differences in demographics or procedural data between stroke and control groups.
  • Only one of 39 calcium metrics, the length of calcium protruding above the annulus, showed a difference, but this did not predict stroke.

Conclusions:

  • This study did not identify any specific calcification patterns that predispose patients to periprocedural stroke after TAVI.
Abstract

Keywords:
Cerebral protection deviceOutcomeTAVRTranscatheter aortic valve replacement

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