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Published on: April 27, 2019
ALSUntangled #70: caffeine
Jessica Hatch1, Paul Barkhaus2, Benjamin Barnes3
1Medical College of Georgia at Augusta University, Augusta, GA, USA.
Abstract:
ALSUntangled reviews alternative and off-label treatments for people living with amyotrophic lateral sclerosis (PALS). Here, we review caffeine which has plausible mechanisms for slowing ALS progression. However, pre-clinical studies are contradictory, and a large case series showed no relationship between caffeine intake and ALS progression rate. While low doses of caffeine are safe and inexpensive, higher doses can cause serious side effects. At this time, we cannot endorse caffeine as a treatment to slow ALS progression.
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