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Junlin Shao¹, Zhiyong Mu¹, Yongjun Xia¹

¹School of Health Science and Engineering, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai, Shanghai 200093, China.

Journal of Agricultural and Food Chemistry

|June 8, 2023

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Lactobacillus plantarum AR113 probiotic helps manage inflammatory bowel disease (IBD) triggered by a Western diet. It improves gut health and reduces inflammation, with its bsh1 gene being crucial for these effects.

Area of Science:

Gastroenterology
Microbiology
Immunology

Background:

The Western diet (WD) is linked to increased inflammatory bowel disease (IBD) susceptibility.
Probiotics, such as Lactobacillus plantarum, are investigated as potential therapeutic agents for IBD.

Purpose of the Study:

To investigate the effects of Lactobacillus plantarum AR113 and a mutant strain (L. plantarum AR113Δbsh1) on a dextran sulfate sodium (DSS)-induced colitis mouse model fed a WD.
To explore the role of the bsh1 gene in the anti-inflammatory function of L. plantarum AR113 in the context of colitis.

Main Methods:

Mice were fed either a WD or a low-sugar, low-fat diet (LD) for four weeks.
Dextran sulfate sodium (DSS) was administered to induce colitis.
Intragastric administration of L. plantarum AR113 or L. plantarum AR113Δbsh1 was performed.

Keywords:

L. plantarum AR113 bile salt hydrolase colitis intestinal mucosal barrier

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Main Results:

L. plantarum AR113 administration significantly alleviated DSS-induced colitis in mice on a WD.
This probiotic improved blood glucose and lipid levels, offered hepatocyte protection, repaired intestinal barrier dysfunction, and inhibited the TLR4/Myd88/TRAF-6/NF-κB inflammatory pathway.
The beneficial effects were not observed with the L. plantarum AR113Δbsh1 strain, suggesting the bsh1 gene is critical.

Conclusions:

Lactobacillus plantarum AR113 demonstrates significant therapeutic potential for managing DSS-induced colitis under WD conditions.
The bsh1 gene within L. plantarum AR113 appears essential for its anti-inflammatory effects and colitis alleviation.
Further research into the role of bile salt hydrolase (BSH) in colitis is warranted.