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pH-Responsive Reversible Granular Hydrogels Based on Metal-Binding Mussel-Inspired Peptides.

Mostafa Rammal1, Chen Li2, James Reeves2

  • 1Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada.

ACS Applied Materials & Interfaces
|June 8, 2023
PubMed
Summary

Researchers developed new injectable granular hydrogels using mussel-inspired peptides. These self-healing, porous scaffolds offer tunable properties for regenerative medicine and tissue engineering applications.

Keywords:
annealed microgelscell scaffoldgranular hydrogelshistidinemetal coordinationmussel-inspired

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Polymer Chemistry

Background:

  • Granular hydrogels from microparticles are promising injectable soft materials.
  • Current annealing methods yield static or mechanically weak scaffolds.
  • Need for dynamic, robust, and injectable scaffolds in regenerative medicine.

Purpose of the Study:

  • To develop novel microgels for creating self-healing, microporous scaffolds.
  • To utilize mussel-inspired peptides for reversible metal-coordination cross-linking.
  • To overcome limitations of existing static and dynamic hydrogel scaffolds.

Main Methods:

  • Functionalization of microgels with mussel-inspired peptides.
  • In situ aggregation via zinc ion coordination at basic pH.
  • Dissociation using metal chelators or acidic conditions.
  • Assessment of scaffold properties (microporosity, self-healing, resilience).

Main Results:

  • Developed peptide-functionalized microgels forming reversible, microporous scaffolds.
  • Achieved self-healing and resilient properties at physiological conditions.
  • Demonstrated tunable scaffold properties via metal coordination.
  • Confirmed cytocompatibility of the annealed granular hydrogel scaffolds.

Conclusions:

  • Peptide-functionalized granular hydrogels offer a versatile platform for regenerative medicine.
  • The developed material provides a tunable, self-healing, and injectable scaffold.
  • Potential applications in tissue engineering and therapeutic delivery are significant.