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Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
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When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
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[Genotype-environment interaction on arterial stiffness: A pedigree-based study].

X H Wang1, S Y Wang1, H X Peng1

  • 1Department of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China.

Beijing Da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences
|June 9, 2023
PubMed
Summary
This summary is machine-generated.

A healthy lifestyle, particularly diet and healthy body mass index (BMI), can reduce the genetic risk of arterial stiffness. Specific gene variants interact with lifestyle factors, influencing arterial stiffness risk.

Keywords:
Arterial stiffnessGene-environment interactionLifestylePedigree

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Area of Science:

  • Cardiovascular Health
  • Genetics
  • Epidemiology

Context:

  • Arterial stiffness is a significant predictor of cardiovascular disease.
  • Genetic factors and lifestyle choices both influence arterial stiffness.
  • The Beijing Fangshan Family Cohort Study provides a valuable dataset for investigating gene-environment interactions.

Purpose:

  • To investigate the potential modification of the association between a healthy lifestyle and arterial stiffness by genetic effects.
  • To estimate the heritability of arterial stiffness (measured by brachial-ankle pulse wave velocity and ankle-brachial index).
  • To assess gene-environment interactions between specific genetic loci and healthy lifestyle factors.

Summary:

  • Heritability estimates for arterial stiffness were 0.360 for brachial-ankle pulse wave velocity and 0.243 for ankle-brachial index.
  • Significant genotype-diet and genotype-BMI interactions were observed, suggesting that lifestyle modifies genetic predisposition to arterial stiffness.
  • Five genetic loci were identified that may influence the relationship between diet, BMI, and arterial stiffness.

Impact:

  • Findings suggest that adopting a healthy lifestyle, including a healthy diet and maintaining a healthy BMI, can mitigate the genetic risk for arterial stiffness.
  • Identifies specific genetic loci (in ADAMTS9-AS2, CDH13, CDKAL1, ATP8B2, and SLC30A8) that interact with lifestyle factors.
  • Provides a foundation for future research into the mechanisms underlying arterial stiffness and personalized cardiovascular risk management.