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Fatal sclerosing mesenteritis: a 7-year-old male autopsy case report

Juan Carlos Celis Pinto1, Lucía Hernández Peláez2, Guillermo Mendoza Pacas1

  • 1Hospital Universitario Central de Asturias (HUCA), Pathology Department, Oviedo, Asturias, Spain.

Autopsy & Case Reports
|June 9, 2023
PubMed

Insights

Sclerosing Mesenteritis (SM) is rare in children. This case report details a fatal pediatric case, highlighting the need for increased awareness and early diagnosis of this potentially severe condition.

Area of Science:

  • Gastroenterology
  • Pediatric Pathology
  • Rare Diseases

Background:

  • Sclerosing Mesenteritis (SM) is a rare condition with diverse clinical presentations.
  • No definitive diagnostic markers currently exist for SM.
  • While typically manageable, SM can rarely present with severe, fatal outcomes.

Observation:

  • A seven-year-old boy experienced sudden cardiorespiratory arrest.
  • Autopsy revealed multicentric SM in the upper mesentery.
  • This led to complications including bowel wall thinning, abdominal bleeding, and bacterial translocation.

Findings:

  • Comprehensive morphological, immunohistochemical, and molecular analyses were performed on the autopsy findings.
  • The case represents the first reported instance of mortality in a pediatric patient due to SM.
  • The findings underscore the atypical and potentially fatal course SM can take in children.

Implications:

  • Emphasizes the critical need for heightened clinical awareness of SM in pediatric populations.
  • Highlights the importance of early diagnosis and appropriate management strategies for Sclerosing Mesenteritis.
  • Suggests further research into diagnostic signatures and treatment protocols for pediatric SM.
Keywords:
AutopsyCase ReportsFatal OutcomePanniculitis, PeritonealPediatrics

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