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Related Experiment Video

Updated: Jul 27, 2025

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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Leveraging longitudinal diffusion MRI data to quantify differences in white matter microstructural decline in normal

Derek B Archer1,2, Kurt Schilling3,4, Niranjana Shashikumar1

  • 1Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN, USA.

Biorxiv : the Preprint Server for Biology
|June 9, 2023
PubMed
Summary
This summary is machine-generated.

White matter microstructural decline is common in aging. Specific tracts, like the cingulum bundle, show greater vulnerability in abnormal aging compared to normal aging.

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Area of Science:

  • Neuroimaging
  • Aging Research
  • Neurodegeneration

Background:

  • Investigating differences in white matter microstructural decline between normal and abnormal aging processes.
  • Understanding the trajectory of brain aging is crucial for identifying neurodegenerative pathways.

Approach:

  • Utilized harmonized, free-water corrected diffusion MRI data from 1,723 participants across multiple longitudinal aging cohorts (ADNI, BLSA, VMAP).
  • Analyzed 4,605 imaging sessions with a mean follow-up of 2.97 years to assess white matter microstructural changes.

Key Points:

  • Global white matter decline was observed in both normal and abnormal aging.
  • Specific white matter tracts, including the cingulum bundle, demonstrated heightened vulnerability in abnormal aging.
  • The free-water metric was particularly sensitive to abnormal aging processes.

Conclusions:

  • White matter microstructural decline plays a significant role across the aging spectrum.
  • Abnormal aging disproportionately affects certain white matter tracts, highlighting potential targets for future research.
  • Further large-scale studies are warranted to elucidate neurodegenerative mechanisms.