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Ranit Pariary1, Sandip Dolui2, Gourav Shome3

  • 1Department of Biophysics, Bose Institute, Salt Lake, Kolkata 700 091, India. bhunia@jcbose.ac.in.

Chemical Communications (Cambridge, England)
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Insulin: Biosynthesis, Chemistry, and Preparation01:25

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The endoplasmic reticulum (ER) of pancreatic β-cells synthesizes preproinsulin, which consists of a signal peptide, A and B chains, and a C-peptide. Preproinsulin is then cleaved and folded into proinsulin, which translocates to the Golgi apparatus for sorting and packaging into secretory granules. In these granules, enzymatic clipping generates insulin and C-peptide.
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment...
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