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Updated: Jul 27, 2025

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
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An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract

Published on: July 1, 2020

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Candida spp. in Human Intestinal Health and Disease: More than a Gut Feeling

Irini A M Kreulen1, Wouter J de Jonge1,2,3, René M van den Wijngaard1,2

  • 1Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam UMC, Location Academic Medical Center, Meibergdreef 69-71, 1105 BK, Amsterdam, the Netherlands.

Mycopathologia
|June 9, 2023
PubMed

Insights

The gut microbiome includes fungi like Candida, which can be linked to intestinal diseases. Research is expanding on Candida

Area of Science:

  • Microbiology
  • Gastroenterology
  • Immunology

Background:

  • Fungi constitute 0.1-1% of the gut microbiome.
  • Candida species are abundant gut fungi.
  • Altered fungal composition is linked to intestinal diseases like IBD and IBS.

Purpose of the Study:

  • To review data on intestinal Candida colonization and disease.
  • To overview biological and technical challenges in studying gut fungi.
  • To highlight Candida albicans strain variation's role.

Main Methods:

  • Culture-dependent techniques.
  • Genomic metabarcoding techniques.
  • Literature review of existing data.

Main Results:

  • Evidence linking Candida spp. to intestinal diseases is growing.
  • Candida spp. are frequently abundant in the gut.
  • Sub-species strain variation in Candida albicans is a new area of study.

Conclusions:

  • Candida spp. may play a role in pediatric and adult intestinal diseases.
  • Further research is needed to overcome technical and biological challenges.
  • Understanding host-microbe interactions involving Candida is crucial.
Keywords:
ColonizationInflammationMicrobiomeMycobiomePretermStrain diversity

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