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Related Experiment Video

Updated: Jul 27, 2025

Novel Production Protocol for Small-scale Manufacture of Probiotic Fermented Foods

Novel Production Protocol for Small-scale Manufacture of Probiotic Fermented Foods

Published on: September 10, 2016

Probiotics and novel probiotic delivery systems.

Samantha J Wala¹, Mecklin V Ragan¹, Nitin Sajankila¹

¹Center for Perinatal Research, Department of Pediatric Surgery, Nationwide Children's Hospital, Columbus, OH, USA.

Seminars in Pediatric Surgery

|June 9, 2023

Summary

Necrotizing enterocolitis (NEC), a common surgical emergency in premature infants, may be treated with probiotics. This review explores current and novel probiotic delivery systems for NEC prevention and treatment.

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Area of Science:

Gastroenterology and Neonatal Research
Microbiology and Immunology

Background:

Necrotizing enterocolitis (NEC) is a severe intestinal disease in premature infants, characterized by dysbiosis.
Probiotics offer potential therapeutic benefits for NEC due to their immunomodulating and antimicrobial properties.

Approach:

This review examines established probiotic delivery systems (planktonic, prebiotics, synbiotics).
It also explores novel systems like biofilm-based and designer probiotics.
The influence of breast milk on probiotic efficacy is also discussed.

Key Points:

Current probiotic research for NEC uses planktonic bacteria, with no FDA-approved options available.
Novel delivery systems and administration with breast milk are critical areas for future research.
Developing an FDA-approved probiotic for NEC presents significant challenges.

Conclusions:

Probiotics hold promise for managing NEC, but further research into advanced delivery systems is essential.
Optimizing probiotic formulations and administration strategies is key to their successful clinical application in NEC.