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Related Experiment Video

Updated: Jul 27, 2025

Binocular Dynamic Visual Acuity in Eyeglass-Corrected Myopic Patients
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Changes in Choroidal Thickness and Retinal Activity with a Myopia Control Contact Lens.

Ana Amorim-de-Sousa1, Jaume Pauné2,3, Sara Silva-Leite1

  • 1Clinical and Experimental Optometry Research Lab (CEORLab), School of Science, University of Minho, 4710-057 Braga, Portugal.

Journal of Clinical Medicine
|June 10, 2023
PubMed
Summary

A new myopia control contact lens (CL) increased choroidal thickness (ChT) and attenuated retinal electrical responses. This radial power gradient CL may impact retinal signaling pathways in myopic eyes.

Keywords:
ERGchoroidal thicknesscontact lensmyopia controlretinal activity

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Area of Science:

  • Ophthalmology
  • Retinal Physiology
  • Myopia Research

Background:

  • Axial elongation in myopia is linked to structural and functional retinal changes.
  • Understanding these changes is crucial for developing effective myopia control strategies.

Purpose of the Study:

  • To investigate the impact of a novel myopia control contact lens (CL) on choroidal thickness (ChT) and retinal electrical responses.
  • To compare the effects of a radial power gradient CL with a single-vision CL.

Main Methods:

  • Ten myopic eyes (spherical equivalents -0.75 to -6.00 D) were fitted with either a single-vision CL or a radial power gradient CL (+1.50 D addition).
  • Choroidal thickness (ChT) at various eccentricities and electroretinogram (ERG) parameters (photopic b-wave, PERG) were recorded after 30 minutes of wear.

Main Results:

  • The radial power gradient CL significantly increased ChT at multiple eccentricities compared to the single-vision CL.
  • The radial power gradient CL significantly decreased the amplitude of the photopic b-wave and PERG components.
  • Negative correlations were observed between a-wave and b-wave amplitudes and ChT.

Conclusions:

  • The radial power gradient CL effectively increased choroidal thickness, consistent with previous findings.
  • These CLs attenuated retinal electrical responses, potentially due to induced peripheral defocus and higher-order aberrations.
  • Observed retinal response attenuation suggests possible retrograde feedback signaling from inner to outer retinal layers.