Using Type I Collagen Gel to Prevent Postoperative Intrauterine Adhesion: A Multicenter Retrospective Study

Area of Science:

• Gynecology
• Reproductive Medicine
• Surgical Innovation

Background:

• Postoperative intrauterine adhesions are a common complication of hysteroscopic procedures.
• These adhesions can lead to infertility, secondary amenorrhea, and recurrent pregnancy loss.
• Effective anti-adhesion strategies are crucial for improving reproductive outcomes.

Purpose of the Study:

• To evaluate the clinical outcomes of using type 1 collagen gel as an anti-adhesion treatment after therapeutic resectoscopy.
• To compare the efficacy and safety of type 1 collagen gel against a sodium hyaluronate and sodium carboxymethylcellulose gel.
• To assess the impact on postoperative intrauterine adhesions and associated adverse events.

Main Methods:

• A randomized controlled trial involving 150 women undergoing therapeutic resectoscopy.
• Patients were assigned to either type 1 collagen gel (Collabarrier®) or a sodium hyaluronate/carboxymethylcellulose gel group.
• Second-look hysteroscopy was performed one month post-surgery to evaluate intrauterine adhesions.

Main Results:

• No significant difference in the incidence rate of postoperative intrauterine adhesions was observed between the type 1 collagen gel group and the control group.
• The frequency and intensity of adhesions showed no statistical differences between the treatment groups.
• No significant differences in adverse events or device-related adverse events were reported for either group.

Conclusions:

• Type 1 collagen gel is an effective and safe option for minimizing postoperative adhesions in intrauterine surgery.
• Its use may help decrease the prevalence of infertility, secondary amenorrhea, and recurrent pregnancy loss.
• The findings support the clinical utility of type 1 collagen gel in gynecological procedures.