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Reduced memory precision in older age is associated with functional and structural differences in the angular gyrus.

Saana M Korkki1, Franziska R Richter2, Helena M Gellersen3

  • 1Department of Psychology, University of Cambridge, Cambridge, UK; Aging Research Center, Karolinska Institute and Stockholm University, Solna, Sweden.

Neurobiology of Aging
|June 10, 2023
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Summary

Older adults show reduced memory precision due to brain changes. The angular gyrus (AG) integrity is key for detailed episodic memory, impacting memory recall accuracy.

Keywords:
AgeingEpisodic memoryHippocampusParietal cortexRetrieval

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Gerontology

Background:

  • Episodic memory decline in aging is linked to reduced representational fidelity.
  • Brain mechanisms driving memory precision loss in older adults are not fully understood.

Purpose of the Study:

  • To investigate the roles of the hippocampus and angular gyrus (AG) in age-related memory precision deficits.
  • To examine how functional and structural changes in these brain regions affect memory recall accuracy.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) to measure blood-oxygen-level-dependent (BOLD) activity during a memory task.
  • Structural magnetic resonance imaging (sMRI) to assess gray matter volume.
  • A continuous scale object feature reconstruction task in young and older adults.

Main Results:

  • Hippocampal BOLD activity related to successful memory retrieval decreased with age.
  • Diminished trial-wise modulation of BOLD signal by memory precision was observed in the AG.
  • AG gray matter volume predicted memory precision in older adults, independent of retrieval success.

Conclusions:

  • Functional and structural integrity of the angular gyrus (AG) is crucial for maintaining episodic memory fidelity in older age.
  • Parietal lobe contributions, specifically the AG, are vital for understanding age-related memory decline.