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Dubowitz syndrome is a rare genetic disorder affecting children, often born preterm. This study suggests infantile eczema is not a required symptom, but hernia and strabismus are more common than previously thought.
Area of Science:
- Genetics
- Pediatrics
- Dermatology
Background:
- Dubowitz syndrome is a rare genetic disorder with variable clinical manifestations.
- Previous literature has emphasized infantile eczema as a key diagnostic feature.
Abstract:
Four children including two siblings with Dubowitz syndrome are presented. All four were preterm or small-for-dates. On the basis of their symptoms, it is suggested that infantile eczema is not an essential sign of the disorder, whereas the high frequency of hernia, strabism and upward slant of the palpebral fissures is underestimated in the literature.