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Updated: Jul 26, 2025

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
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Enabling Deoxygenative C(sp2)-C(sp3) Cross-Coupling for Parallel Medicinal Chemistry.

Wei Liu1, James Mulhearn1, Bo Hao1

  • 1Discovery Chemistry, Janssen Research & Development LLC, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.

ACS Medicinal Chemistry Letters
|June 14, 2023
PubMed
Summary

An automated deoxygenative coupling method was developed for aryl bromides and alcohols, enabling parallel medicinal chemistry. This high-throughput protocol enhances drug discovery by utilizing diverse alcohol building blocks.

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