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Insights into the relationship between persistent antibody secretion and metabolic programming - A question for
Olivia T M Bucheli1, Klaus Eyer1
1Laboratory for Functional Immune Repertoire Analysis, Institute of Pharmaceutical Sciences, D-CHAB, ETH Zürich, 8093 Zürich, Switzerland.
Immunology Letters
|June 14, 2023
Summary
Vaccine-induced antibody protection relies on long-lived plasma cells. This review explores how cellular metabolism influences plasma cell function and longevity, crucial for long-term immunity.
Area of Science:
- Immunology
- Cellular Metabolism
- Vaccinology
Background:
- Humoral immunity and vaccine efficacy depend on antibody quantity and plasma cell persistence.
- Understanding plasma cell generation, selection, and maintenance is vital for immunity, autoimmune diseases, and multiple myeloma.
- Recent research highlights the link between plasma cell behavior and their metabolic state.
Approach:
- This review synthesizes current knowledge on metabolic pathways impacting immune cell function.
- It specifically examines how metabolism influences plasma cell differentiation and longevity.
- The review also discusses technologies for metabolic profiling and identifies future research challenges.
Key Points:
- Metabolic programs are critical drivers of immune cell functions.
- Specific metabolic pathways dictate plasma cell differentiation and lifespan.
- Metabolism is both a cause and consequence of altered cellular behavior in plasma cells.
Conclusions:
- Metabolic insights are fundamental to understanding long-term immunity and vaccine responses.
- Further technological advancements are needed to fully elucidate the role of metabolism in plasma cell biology.
- This knowledge can inform therapeutic strategies for immune-related disorders.