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Related Concept Videos

Microbiota of the Stomach and Small Intestine01:27

Microbiota of the Stomach and Small Intestine

The human gastrointestinal (GI) tract is characterized by distinct physicochemical conditions that shape its microbial communities. Among these, the stomach presents a particularly challenging environment for microbial colonization due to its highly acidic pH, ranging from 1 to 3. This extreme acidity effectively limits microbial density. However, certain acid-tolerant microorganisms are capable of surviving in this niche. Notably, Helicobacter pylori can colonize the gastric mucosa,...

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Correction: Peptine et al. Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) and Vancomycin-Resistant Enterococci (VRE) in Nosocomial Infections: A Systematic Review of Resistance, Pathogenesis, and Clinical Management. <i>Microorganisms</i> 2026, <i>14</i>, 428.

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Related Experiment Video

Updated: Jun 29, 2026

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device
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Microfluidics: Insights into Intestinal Microorganisms.

Ping Qi1,2,3, Jin Lv1,2,3, Xiangdong Yan1,2,3

  • 1The First Clinical Medical College, Lanzhou University, Lanzhou 730000, China.

Microorganisms
|June 15, 2023
PubMed
Summary
This summary is machine-generated.

Microfluidics technology offers innovative methods for studying the gut microbiome. This review highlights microfluidic intestine-on-a-chip models and drug delivery systems for intestinal microbial research.

Keywords:
droplet microfluidelectrospray microfluidintestinal microorganismsintestine-on-a-chipmicrofluidic drug delivery systemmicrofluidics

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Area of Science:

  • Biotechnology
  • Microbiology
  • Systems Biology

Background:

  • The gut microbiome plays crucial roles in host physiology.
  • Studying intestinal microorganisms is vital for understanding health and disease.
  • Traditional methods for microbial analysis have limitations.

Purpose of the Study:

  • To provide a comprehensive review of microfluidics applications in intestinal microbial research.
  • To highlight the significance of microfluidic intestine-on-a-chip models.
  • To discuss the potential of microfluidic drug delivery systems in this field.

Main Methods:

  • Review of existing literature on microfluidics in gut microbiome research.
  • Detailed examination of microfluidic intestine-on-a-chip technologies.
  • Analysis of microfluidic drug delivery systems for intestinal applications.

Main Results:

  • Microfluidics enables precise manipulation and analysis of microscale fluids and channels.
  • Microfluidic intestine-on-a-chip models offer advanced platforms for simulating gut environments.
  • Microfluidic drug delivery systems show promise for targeted interventions in the gut.

Conclusions:

  • Microfluidics technology is revolutionizing intestinal microbial research.
  • Microfluidic intestine-on-a-chip and drug delivery systems present significant advantages and future prospects.
  • This review establishes microfluidics as a key technology for advancing gut microbiome science.