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Annotated protein network analysis linking oral diseases

Mukesh Kumar Sharma1,2, Vivek Kumar Srivastav1, Chetan Kumar Joshi3

  • 1Department of Biotechnology, Maharaj Vinayak Global University, Jaipur Rajasthan, India.

Bioinformation
|June 16, 2023
PubMed

Insights

Oral cancer is a growing global health concern. This study maps protein interactions in oral bacteria, identifying potential therapeutic targets for oral disease drug discovery.

Area of Science:

  • Molecular biology
  • Bioinformatics
  • Oral microbiology

Background:

  • Oral cancer is a significant and increasing global health issue.
  • Understanding molecular interactions is crucial for identifying therapeutic targets.
  • Elucidating protein networks and signaling pathways in oral bacteria is key.

Purpose of the Study:

  • To construct a protein-protein interaction network for oral bacterial proteins.
  • To identify potential therapeutic drug candidates for oral diseases.
  • To analyze functional annotations and cell signaling pathways.

Main Methods:

  • Utilized the STRING online software to build a molecular genetics interaction network.
  • Employed Cystoscope software for network analysis, identifying nodes and edges.
  • Analyzed network topology, including average node order.

Main Results:

  • Developed the AZURIN molecular genetics interaction network for oral bacterial proteins.
  • Identified 11 nodes and 16 edges within the constructed network.
  • Characterized network properties, such as an average node order of 2.91.

Conclusions:

  • The study provides valuable data on protein-protein interactions in oral bacteria.
  • The identified network serves as a foundation for discovering novel therapeutic drug candidates.
  • This research contributes to understanding oral disease mechanisms and potential interventions.
Keywords:
NetworkingSTRINGbacteriacystoscopeoral cancer

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