Advancement in COVID-19 detection using nanomaterial-based biosensors

Area of Science:

• Biotechnology and Nanomaterials Science
• Infectious Disease Diagnostics
• Global Biosecurity

Background:

• The COVID-19 pandemic highlighted the urgent need for effective viral detection strategies.
• Conventional molecular methods for Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection are often slow, labor-intensive, and lack accuracy.
• These limitations hinder rapid response and control of viral outbreaks.

Purpose of the Study:

• To systematically review nanomaterials-based biosensors for SARS-CoV-2 detection.
• To summarize the mechanisms, characteristics, and applications of these advanced biosensors.
• To discuss current challenges and future trends in biosensor development for pathogen detection.

Main Methods:

• Review of interdisciplinary advances in nanomaterials and biotechnology.
• Focus on electrochemical, field-effect transistor, plasmonic, and colorimetric biosensors.
• Analysis of biosensors utilizing nucleic acid and antigen-antibody interactions for SARS-CoV-2 detection.

Main Results:

• Nanomaterials-based biosensors demonstrate high efficiency, reliability, sensitivity, and rapidity in detecting SARS-CoV-2.
• These biosensors offer a significant improvement over conventional diagnostic methods.
• Various biosensor types show promise for rapid and ultrasensitive pathogen identification.

Conclusions:

• Nanomaterials-based biosensors represent a significant advancement in healthcare diagnostics for rapid pathogen detection.
• They provide a viable alternative to overcome the bottlenecks associated with traditional SARS-CoV-2 detection methods.
• Continued research and development in biosensor technology are essential for addressing future global health challenges.