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Prognostic Value of Lymph Node Density in Node-Positive Oral Squamous Cell Carcinoma
Amol Padegaonkar1, Sourabh Sharma2, Mandar Deshpande3
1Department of Surgical Oncology, Apollo Hospital, Seepat Road, Bilaspur, C.G India.
Indian Journal of Surgical Oncology
|June 16, 2023
Summary
Lymph node density (LND) significantly impacts survival in oral cavity cancer patients. Higher LND indicates a poorer prognosis, highlighting its importance in treatment planning for head and neck cancers.
Area of Science:
- Oncology
- Head and Neck Cancer Research
- Surgical Pathology
Background:
- Lymph node status is a critical prognostic indicator in head and neck cancers.
- Accurate prognostic factors are essential for tailoring treatment strategies in oral cavity squamous cell carcinoma.
Purpose of the Study:
- To evaluate the prognostic significance of lymph node density (LND) in node-positive oral cavity squamous cell carcinoma patients.
- To determine if LND predicts survival outcomes after surgery and adjuvant radiotherapy.
Main Methods:
- Retrospective analysis of 61 oral cavity squamous cell carcinoma patients with positive lymph nodes treated with surgery and adjuvant radiotherapy.
- Calculation of lymph node density (LND) for each patient.
- Assessment of 5-year overall survival (OS) and 5-year disease-free survival (DFS) in relation to LND.
Main Results:
- Patients with LND ≤ 0.05 had significantly better 5-year OS (56.1 months) and DFS (50.5 months) compared to those with LND > 0.05 (OS: 40.0 months, DFS: 15.8 months).
- Univariate analysis identified nodal status, disease stage, and LND as significant predictors.
- Multivariate analysis confirmed LND as the sole independent predictor of prognosis.
Conclusions:
- Lymph node density is a crucial prognostic factor for 5-year OS and DFS in oral cavity squamous cell carcinoma.
- LND provides valuable prognostic information beyond traditional staging for patients undergoing surgery and adjuvant radiotherapy.
