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Related Experiment Video

Updated: Jul 26, 2025

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model

Published on: August 11, 2023

Thyroid Dysfunction: An Alternate Plausibility in Perimenopausal Women!

S M R Usha¹, C M Bindu¹, N Chandrika²

¹Department of Biochemistry, Rajarajeswari Medical College and Hospital, Bengaluru, Karnataka, India.

Journal of Mid-Life Health

|June 16, 2023

Summary

Thyroid disorders are common in perimenopausal women, with hypothyroidism increasing with age. Early screening for thyroid dysfunction in women aged 46-55 is crucial for timely management and preventing complications.

Keywords:

Estrogen Hypothyroidism Menopause Thyroid-stimulating hormone

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Published on: March 17, 2023

Area of Science:

Endocrinology
Women's Health
Reproductive Medicine

Background:

Perimenopause is characterized by declining ovarian activity, increasing health risks.
Thyroid disorder symptoms can mimic menopausal symptoms, potentially leading to missed diagnoses.
Undiagnosed thyroid disorders in perimenopausal women can result in serious complications.

Purpose of the Study:

To screen women of perimenopausal age for thyroid disorders.
To investigate age-related variations in thyroid hormone levels during perimenopause.

Main Methods:

148 healthy women aged 46-55 were divided into two groups (46-50 and 51-55 years).
Thyroid profile tests including TSH, total T3, and total T4 were performed.
Prevalence of subclinical hypothyroidism (SCH) and overt hypothyroidism (OH) was assessed.

Main Results:

14.9% of women had SCH and 5.4% had OH.
Hypothyroidism prevalence increased with age, with Group II (51-55 years) showing higher rates of OH.
TSH levels were significantly higher in Group II compared to Group I (P=0.002).

Conclusions:

Screening perimenopausal women for thyroid disorders ensures early detection and management.
Timely intervention can reduce morbidity and associated complications.
Thyroid dysfunction prevalence increases with age during the perimenopausal transition.