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Updated: Jul 26, 2025
Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
Published on: April 7, 2021
High positive end-expiratory pressure ventilation mitigates the progression from unilateral pulmonary contusion to
Tobias Landeck1, Henrike Schwarz, Sören Hammermüller
1From the Department of Anesthesiology and Intensive Care Medicine (T.L., H.S., S.H., M.L.), University Hospital Leipzig; Department of Pediatric Cardiology and Intensive Care Medicine (H.S.), Georg-August-University Göttingen, University Medical Center, Göttingen; Department of Anesthesiology, Intensive Care Medicine, Emergency Medicine, and Pain Therapy (T.L., U.G., C.N., S.J.W., A.W.R.), Heinrich-Braun-Hospital, Zwickau; Innovation Center Computer Assisted Surgery (ICCAS) (T.L., U.G., A.W.R.), University of Leipzig, Medical Faculty, Leipzig, Germany; Bonitas Holding GmbH (S.H.), Herford; Medizinisch-Experimentelles Zentrum (K.N.), University of Leipzig, Medical Faculty, Leipzig; Department Diagnostic and Interventional Radiology (S.R.), Heinrich-Braun-Hospital Zwickau, Zwickau; Department of Urology (J.R.), Sana Kliniken Leipziger Land, Borna; Department of Anesthesiology, Intensive Care and Emergency Medicine, Pain Therapy (H.W.), Bergmannstrost Hospital Halle; Martin-Luther-University of Halle-Wittenberg (H.W.), Halle; Department of Anesthesiology and Intensive Care Medicine (F.G.), University Hospital Augsburg, Augsburg; Deutsche Fachpflege Holding, GmbH (S.H.), Herford; and Department for Horses, Faculty of Veterinary Medicine, Leipzig University, Leipzig, Germany (W.B.).
Background:
Pulmonary contusion (PC) is common in severely traumatized patients and can lead to respiratory failure requiring mechanical ventilation (MV). Ventilator-induced lung injury (VILI) might aggravate lung damage. Despite underrepresentation of trauma patients in trials on lung-protective MV, results are extrapolated to these patients, potentially disregarding important pathophysiological differences.
Methods:
Three MV protocols with different positive end-expiratory pressure (PEEP) levels: ARDSnetwork lower PEEP (ARDSnet-low), ARDSnetwork higher PEEP (ARDSnet-high), and open lung concept (OLC) were applied in swine for 24 hours following PC. Gas exchange, lung mechanics, quantitative computed tomography, and diffuse alveolar damage (DAD) score were analyzed. Results are given as median (interquartile range) at 24 hours. Statistical testing was performed using general linear models (group effect) over all measurement points and pairwise Mann-Whitney U tests for DAD.
Results:
There were significant differences between groups: PEEP ( p < 0.0001) ARDSnet-low (8 [8-10] cmH 2 O), ARDSnet-high (12 [12-12] cmH 2 O), OLC (21 [20-22] cmH 2 O). The fraction of arterial partial pressure of oxygen and inspired oxygen fraction ( p = 0.0016) was lowest in ARDSnet-low (78 (73-111) mm Hg) compared with ARDSnet-high (375 (365-423) mm Hg) and OLC (499 (430-523) mm Hg). The end-expiratory lung volume (EELV) differed significantly ( p < 0.0001), with highest values in OLC (64% [60-70%]) and lowest in ARDSnet-low (34% [24-37%]). Costa's surrogate for mechanical power differed significantly ( p < 0.0001), with lowest values for ARDSnet-high (73 [58-76]) compared with OLC (105 [108-116]). Diffuse alveolar damage was lower in ARDSnet-high compared with ARDSnet-low (0.0007).
Conclusion:
Progression to ARDS, 24 hours after PC, was mitigated by OLC and ARDSnet-high. Both concepts restored EELV. ARDSnet-high had the lowest mechanical power surrogate and DAD. Our data suggest, that ARDSnet-high restored oxygenation and functional lung volume and reduced physiological and histological surrogates for VILI. ARDSnet-low generated unfavorable outcomes, such as loss of EELV, increased mechanical power and DAD after PC in swine. The high respiratory rate in the OLC may blunt favorable effects of lung recruitment.
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