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An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use
Published on: May 24, 2024
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Increased 68 Ga-FAPI Uptake in Benign Metastasizing Leiomyoma
Simin Wu1, Jiayu Cai1, Qi Chen2
1From the Department of Nuclear Medicine and Minnan PET Center, Xiamen Cancer Center.
Clinical Nuclear Medicine
|June 19, 2023
Summary
Benign metastasizing leiomyomas (BMLs) are rare tumors that can spread outside the uterus. This study shows 68 Ga-FAPI PET/CT may help evaluate these BMLs, revealing fibroblast activity.
Area of Science:
- Oncology
- Radiology
- Nuclear Medicine
Background:
- Benign metastasizing leiomyomas (BMLs) are rare, benign, disseminated extrauterine tumors.
- These tumors typically occur in women with a history of uterine leiomyomas, sometimes years after hysterectomy.
Observation:
- A case study involving a 37-year-old woman with BMLs metastasized to the lung and pelvis.
- 18F-FDG and 68Ga-FAPI PET/CT imaging was performed to evaluate the metastatic lesions.
Findings:
- Metastatic BML lesions showed low 18F-FDG uptake, suggesting minimal glucose metabolism.
- Elevated 68Ga-FAPI uptake was observed in the metastatic lesions, indicating significant activated fibroblast accumulation.
Implications:
- 68Ga-FAPI PET/CT may offer a valuable tool for assessing BMLs.
- This imaging modality can potentially differentiate BMLs by highlighting fibroblast activity.
