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Updated: Jul 26, 2025
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A Neonatal Mouse Spinal Cord Compression Injury Model
Published on: March 27, 2016
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Malignant spinal cord compression in the paediatric population-a systematic review, meta-analysis
N A Quraishi1, N Palliyil1, Mohamed A Hassanin2,3
1Centre for Spinal Studies and Surgery, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, NG7 2UH, UK.
Summary
Malignant spinal cord compression (MSCC) in children is most commonly caused by neuroblastoma and sarcoma. Prompt diagnosis and multimodality treatment are crucial for neurological recovery in pediatric cancer patients.
Area of Science:
- Pediatric Oncology
- Neurology
- Systematic Review
Background:
- Malignant spinal cord compression (MSCC) affects 3-5% of children with primary tumors, potentially causing permanent neurological deficits.
- Prompt diagnosis and treatment are essential for managing MSCC in pediatric patients.
- This systematic review aims to inform national guidelines for MSCC in children under 18.
Approach:
- A systematic review adhering to PRISMA guidelines was conducted.
- Searched English-language literature from 1999-2022 using terms like 'MSCC in children,' 'pediatric,' and 'metastases.'
- Excluded case reports/series with fewer than 10 patients, analyzing 7 eligible articles (Level III/IV evidence).
Key Points:
- Neuroblastoma (62.7%) and sarcoma (14.2%) are the leading causes of pediatric MSCC.
- Motor deficits (95.6%) were the most common presenting symptom, followed by pain (65.4%).
- A median delay of 26 days occurred between symptom onset and diagnosis, impacting prognosis.
Conclusions:
- Neuroblastoma and sarcoma are primary drivers of MSCC in children, with soft tissue sarcomas more common in older children (>5 years).
- Multimodality treatment (chemotherapy, radiotherapy, surgery) is recommended, with early surgical consideration for rapid neurological decline.
- Future spinal deformities are a risk following laminectomy/decompression and asymmetrical radiation.
