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Specifics of Experimental Modeling 8-OH-DPAT-Induced Perseverative Behavior in Mice.

N V Kudryashov¹, A V Volkova², A A Shimshirt²

¹V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia. kunvi@mail.ru.

Bulletin of Experimental Biology and Medicine

|June 20, 2023

Summary

The serotonin 5-HT1A receptor agonist 8-OH-DPAT affects mouse behavior in a Y-maze. It impairs spontaneous alternation and activity, but promotes perseverative behavior after habituation and food reward.

Keywords:

5-HT1A receptors 8-OH-DPAT obsessive-compulsive disorder perseverative behavior

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Area of Science:

Neuroscience
Pharmacology
Behavioral Science

Background:

The serotonin 5-HT1A receptor plays a crucial role in regulating mood and behavior.
Understanding the effects of 5-HT1A receptor agonists is vital for developing treatments for behavioral disorders.

Purpose of the Study:

To investigate the impact of the 5-HT1A receptor agonist 8-OH-DPAT on spontaneous alternation behavior in mice.
To evaluate the influence of habituation and food reward on 8-OH-DPAT's behavioral effects.
To establish a suitable model for studying perseverative behavior and potential anticompulsive agents.

Main Methods:

Mice were administered 8-OH-DPAT via intraperitoneal injection at doses of 1, 2, and 4 mg/kg.
Spontaneous alternation behavior and locomotor activity were assessed using the Y-maze test.
Experiments were conducted under conditions without and with a habituation procedure and food reward.

Main Results:

8-OH-DPAT decreased spontaneous alternation and locomotor activity when administered without habituation.
Following habituation and food deprivation, 8-OH-DPAT increased repeated choices of goal arms, indicating perseverative behavior, without altering locomotor activity.
The Y-maze test with habituation and food reward effectively modeled perseverative behavior.

Conclusions:

The 5-HT1A receptor agonist 8-OH-DPAT differentially affects mouse behavior based on experimental conditions.
The Y-maze procedure with habituation and food reward is a valuable model for studying perseverative behavior.
This model can be utilized for screening and developing new anticompulsive substances.