Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Physiology of Enteric Nervous System and Gut Health01:05

Physiology of Enteric Nervous System and Gut Health

329
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
329
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

325
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
325
Anatomy of the Intestines01:23

Anatomy of the Intestines

72.6K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
72.6K
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

1.4K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
1.4K
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

763
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
763
Bulimia Nervosa01:30

Bulimia Nervosa

166
Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
166

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Investigation of Bacterial Infections and Antibiotic Resistance Patterns Among Clinical Isolates in the Center of Iran.

International journal of microbiology·2025
Same author

Ascorbic Acid Significantly Decreases Creatine Kinase Plasma Levels in an Animal Model of Statin/Fibrate-Induced Myopathy.

Advances in pharmacological and pharmaceutical sciences·2022
Same author

Modulatory Effect of Probiotics on Proinflammatory Cytokine Levels in Acrylamide-Treated Rats.

Biochemistry research international·2021
Same author

Ginger Extract Increases GLUT-4 Expression Preferentially Through AMPK Than PI3K Signalling Pathways in C2C12 Muscle Cells.

Diabetes, metabolic syndrome and obesity : targets and therapy·2020
Same author

Molecular Targeting and Rational Chemotherapy in Acute Myeloid Leukemia.

Journal of experimental pharmacology·2020
Same author

Genetic Characterization and Risk Stratification of Acute Myeloid Leukemia.

Cancer management and research·2020

Related Experiment Video

Updated: Jul 26, 2025

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice
07:49

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

Published on: June 2, 2022

3.3K

Gut Microbiota and Neuropsychiatric Disorders.

Reza Bidaki1, Seyed Hossein Hekmati Moghaddam2, Maryam Sadeh3

  • 1Research Center of Addiction and Behavioral Sciences, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Basic and Clinical Neuroscience
|June 22, 2023
PubMed
Summary
This summary is machine-generated.

Gut microbiota dysbiosis is linked to neurological and behavioral disorders. More research is needed to develop treatments that restore gut health for these conditions.

Keywords:
Alzheimer's diseaseAutism spectrum disorderBrain-gut axisMicrobiotaNervous system diseasesParkinson disease

More Related Videos

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

28.4K
A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
09:18

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

Published on: July 28, 2023

2.7K

Related Experiment Videos

Last Updated: Jul 26, 2025

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice
07:49

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

Published on: June 2, 2022

3.3K
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

28.4K
A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
09:18

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

Published on: July 28, 2023

2.7K

Area of Science:

  • Neuroscience
  • Microbiology
  • Gastroenterology

Background:

  • Gut microbiota dysbiosis is hypothesized to contribute to neurological and behavioral diseases.
  • Conditions implicated include depression, autism spectrum disorder, Parkinson disease, multiple sclerosis, stroke, and Alzheimer's disease.
  • Existing knowledge of the gut-brain axis is insufficient for direct clinical application.

Purpose of the Study:

  • To review current understanding of the gut-brain axis in neurological diseases.
  • To highlight the gap between current knowledge and clinical application.
  • To emphasize the need for comprehensive research into gut microbiota restoration.

Main Methods:

  • Literature review of studies on gut microbiota and neurological disorders.
  • Analysis of the brain-gut axis in relation to various neuropsychiatric conditions.
  • Identification of research gaps and future directions.

Main Results:

  • The gut microbiome plays a significant role in the development of numerous brain disorders.
  • Current therapeutic strategies are limited due to incomplete understanding.
  • A comprehensive approach is required to assess interventions.

Conclusions:

  • Gut microbiota dysbiosis is a critical factor in neuropsychological disorders.
  • Further research is essential to develop effective therapeutic regimens.
  • Restoring gut microbial balance is a promising avenue for future treatments.