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The dysregulation of lncRNAs by epigenetic factors in human pathologies

Yanli Zhang1, Xiaocong Wang2, Chen Zhang3

  • 1Central Laboratory, The First Hospital of Jilin University, Changchun, Jilin, China; Key Laboratory of Organ Regeneration and Transplantation, Ministry of Education, Changchun, Jilin 130021, China; Department of Echocardiography, The First Hospital of Jilin University, Changchun, Jilin, China.

Drug Discovery Today
|June 22, 2023
PubMed

Insights

Long noncoding RNAs (lncRNAs) are crucial in diseases like cancer and autoimmune diseases (ADs). This review explores how epigenetic factors dysregulate lncRNAs, offering insights for new AD therapies.

Area of Science:

  • Molecular Biology
  • Genetics
  • Immunology

Background:

  • Long noncoding RNAs (lncRNAs) play significant roles in the initiation and progression of various human diseases.
  • Dysregulation of lncRNAs is implicated in pathologies such as cancers and autoimmune diseases (ADs).
  • Understanding the complex regulatory networks of lncRNAs is essential for developing novel therapeutic strategies for ADs.

Purpose of the Study:

  • To review the mechanisms by which epigenetic factors dysregulate lncRNAs in pathological conditions.
  • To discuss the involvement of lncRNA epigenetic regulators in immune responses and autoimmune diseases.
  • To provide a theoretical foundation for the clinical application of lncRNAs in ADs.

Main Methods:

  • Literature review summarizing epigenetic regulation of lncRNAs.
  • Analysis of lncRNA dysregulation by epigenetic factors including RNA-binding proteins and chemical modifications.
  • Discussion of the roles of lncRNA epigenetic regulators in immune response and ADs.

Main Results:

  • Epigenetic factors such as RNA-binding proteins, chemical modifications (e.g., N6-methyladenosine, DNA methylation, histone modification), microRNA, and alternative splicing contribute to lncRNA dysregulation.
  • lncRNA epigenetic regulators are involved in immune responses and the pathogenesis of autoimmune diseases.
  • A complex interplay exists between epigenetic factors and lncRNAs in disease development.

Conclusions:

  • Epigenetic dysregulation of lncRNAs is a key factor in the pathogenesis of autoimmune diseases.
  • Targeting the epigenetic regulation of lncRNAs presents a promising avenue for developing new therapies for ADs.
  • Further research into the epigenetic factor-lncRNA network will advance the clinical application of lncRNAs for treating ADs.
Keywords:
N6-methyladenosineautoimmune diseaseepigenetic modulatorinflammationlong noncoding RNA

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