Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Kaposi's sarcoma in a patient with SLE.

D I Greenfield, P Trinh, A Fulenwider

    The Journal of Rheumatology
    |June 1, 1986
    PubMed
    Summary

    A woman with systemic lupus erythematosus (SLE) developed Kaposi's sarcoma while on corticosteroids. This rare case highlights the potential for aggressive Kaposi's sarcoma in SLE patients, even after immunosuppressive therapy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Itch in skin of colour: a multicentre cross-sectional study.

    The British journal of dermatology·2021
    Same author

    Temporal and Environmental Factors Driving <i>Vibrio Vulnificus</i> and <i>V. Parahaemolyticus</i> Populations and Their Associations With Harmful Algal Blooms in South Carolina Detention Ponds and Receiving Tidal Creeks.

    GeoHealth·2020
    Same author

    Subgingival Microbiota and Longitudinal Glucose Change: The Oral Infections, Glucose Intolerance and Insulin Resistance Study (ORIGINS).

    Journal of dental research·2019
    Same author

    A spatial assessment of baseline nutrient and water quality values in the Ashepoo-Combahee-Edisto (ACE) Basin, South Carolina, USA.

    Marine pollution bulletin·2015
    Same author

    Subacute bacterial endocarditis with polyarthritis mimicking thrombotic thrombocytopenic purpura: a case report.

    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2008
    Same author

    Giant Cell Arteritis in AJ Americans.

    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2008

    Area of Science:

    • Immunology
    • Oncology
    • Rheumatology

    Background:

    • Systemic lupus erythematosus (SLE) is an autoimmune disease often managed with immunosuppressive therapies, including corticosteroids.
    • Corticosteroids and other immunosuppressants can increase the risk of opportunistic infections and malignancies.
    • Kaposi's sarcoma (KS) is a cancer associated with human herpesvirus 8 (HHV-8) and immunosuppression.

    Observation:

    • A 31-year-old female patient with SLE, undergoing chronic corticosteroid treatment, presented with Kaposi's sarcoma.
    • The patient received a single dose of intravenous cyclophosphamide for central nervous system vasculitis.
    • She subsequently developed disseminated Kaposi's sarcoma involving the skin, lungs, and other visceral organs.

    Findings:

    • This case represents the first documented instance of widespread Kaposi's sarcoma in a patient diagnosed with SLE.
    • The rapid progression and dissemination of KS occurred despite immunosuppressive treatment.

    Implications:

    • This case underscores the critical need for vigilant monitoring of opportunistic infections and malignancies in SLE patients, particularly those on long-term immunosuppression.
    • Further research may be warranted to understand the specific interplay between SLE, immunosuppressive therapies, and the development of Kaposi's sarcoma.
    • Clinicians should consider KS in the differential diagnosis of skin lesions or visceral masses in SLE patients receiving immunosuppressive treatment.

    Related Experiment Videos