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A COMPARATIVE REVIEW OF THE USE OF DANIO RERIO (ZEBRAFISH) AS A MODEL OBJECT IN PRECLINICAL STUDIES
D Kachanov1, L Elistratov1, H Guseinov1
1North-western State Medical University named after I.I. Mechnikov, Ministry of Health of Russia, St. Petersburg, Russia.
Georgian Medical News
|June 24, 2023
Summary
Danio rerio, or Zebrafish, are increasingly used in preclinical research due to their advantageous characteristics and cost-effectiveness. These fish offer a versatile model for drug studies, including stress and depression, before mammalian testing.
Area of Science:
- Pharmacology and Toxicology
- Developmental Biology
- Neuroscience
Background:
- Danio rerio (Zebrafish) possess unique morphological, physiological, genetic, and embryological traits making them suitable for preclinical research.
- Economic benefits and rapid breeding cycles further enhance their utility as a model organism.
- Extensive research highlights their application across various scientific disciplines.
Approach:
- A comprehensive review of domestic and international literature was conducted.
- The review focused on the utilization of Zebrafish in toxicological, pharmacological, and embryological studies.
- Data synthesis aimed to summarize current knowledge on Zebrafish as a preclinical model.
Key Points:
- Zebrafish serve as a versatile model for diverse preclinical drug studies.
- Their application in modeling novelty stress and experimental depression is particularly noteworthy.
- They enable cost-effective preliminary evaluations of pharmacological agents.
Conclusions:
- Danio rerio (Zebrafish) are a valuable and adaptable model organism for preclinical research.
- Their use facilitates efficient and economical drug testing prior to mammalian studies.
- Continued research will likely expand the scope of Zebrafish applications in biomedical science.
