SPECIFICS OF PRESCRIBING ANTIRETROVIRAL DRUGS IN THE TREATMENT OF HIV INFECTION

Area of Science:

• Infectious Diseases
• Virology
• Pharmacology

Background:

• Human immunodeficiency virus (HIV) infection presents a significant global health challenge.
• Effective management relies on highly active antiretroviral therapy (HAART) targeting viral replication.
• Numerous antiretroviral drugs exist, acting on various stages of the HIV life cycle.

Purpose of the Study:

• To provide a theoretical review of contemporary highly active antiretroviral therapy (HAART) for HIV infection.
• To analyze commonly prescribed treatment regimens for patients diagnosed with HIV.
• To identify prevalent drug combinations used in HIV treatment.

Main Methods:

• Theoretical review of modern highly active antiretroviral therapy (HAART) strategies.
• Analysis of prescribed treatment regimens for HIV-infected patients.
• Identification and categorization of drug combinations.

Main Results:

• Two primary HAART combinations were identified as most frequently prescribed.
• Combination 1: Nucleoside reverse transcriptase inhibitors (NRTIs) + Protease Inhibitors (PIs).
• Combination 2: Nucleoside reverse transcriptase inhibitors (NRTIs) + Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs).

Conclusions:

• Current HIV treatment predominantly utilizes specific combinations of antiretroviral drugs.
• NRTI-based regimens, combined with either PIs or NNRTIs, represent the most common therapeutic approaches.
• Understanding these prevalent regimens is crucial for optimizing HIV patient care and management.